Oral Nano-Insulin Therapy: Current Progress on Nanoparticle-Based Devices for Intestinal Epithelium-Targeted Insulin Delivery
نویسندگان
چکیده
منابع مشابه
Intestinal mucoadhesive devices for oral delivery of insulin
Oral delivery of proteins such as insulin has been a long-lasting challenge owing to gastrointestinal degradation and poor permeability of therapeutic macromolecules across biological membranes. We have developed mucoadhesive intestinal devices for oral delivery of insulin to address this challenge. Here we demonstrate a combination of intestinal devices and a permeation enhancer, dimethyl palm...
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Diabetes is a set of diseases characterized by defects in insulin utilization, either through autoimmune destruction of insulin-producing cells (Type I) or insulin resistance (Type II). Treatment options can include regular injections of insulin, which can be painful and inconvenient, often leading to low patient compliance. To overcome this problem, novel formulations of insulin are being inve...
متن کاملCurrent Status of the Oral Delivery of Insulin
conducted involving a wide range of protein therapeutics for various conditions. Most of the proteins have been successfully applied in therapy, mainly as parenterals. An oral dosage form is the preferred form of delivery because of ease of administration, patient compliance, and cost. Major hurdles must be overcome before the oral delivery of a protein becomes a reality. Among the proteins, or...
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The potential of complexation hydrogels composed of poly(methacrylic acid) grafted with poly(ethylene glycol) (P(MAA-g-EG)) for oral dosage forms of insulin is reviewed. The complexation hydrogels exhibit unique pH-responsive characteristics in which interpolymer complexes are formed and dissociated, respectively, in acidic and neutral/basic environments. The hydrogels are capable of highly inc...
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Diabetic cases have increased rapidly in recent years throughout the world. Currently, for type-1 diabetes mellitus (T1DM), multiple daily insulin (MDI) injections is the most popular treatment throughout the world. At this juncture, researchers are trying to develop different insulin delivery systems, especially through oral and pulmonary route using nanocarrier based delivery system. This nex...
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ژورنال
عنوان ژورنال: Journal of Nanomedicine & Nanotechnology
سال: 2011
ISSN: 2157-7439
DOI: 10.4172/2157-7439.s4-007